Mta wiki offline3/6/2023 ![]() It shows a very broad expression pattern and is strongly expressed in many tissues. This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. MTA2 is acetylated at lysine 152 within the BAH domain Function MTA2 domains include, a BAH (Bromo-Adjacent Homology), an ELM2 (egl-27 and MTA1 homology), a SANT domain (SWI, ADA2, N-CoR, TFIIIB-B), and a GATA-like zinc finger. The murine Mta2 consists of a 3.1-kb protein-coding transcript to code a protein of 668 amino acids, and five non-coding RNAs transcripts, ranging from 620-bp to 839-bp.Īmino acid sequence of MTA2 shares 68.2% homology with MTA1’s sequence. The remaining four MTA2 transcripts are non-coding RNA transcripts ranging from 532-bp to 627-bp. The 8.6-kb long human MTA2 gene contains 20 exons and seven transcripts inclusive of three protein-coding transcripts but predicted to code for two polypeptides of 688 amino acids and 495 amino acids. MTA2 is localized on chromosome 11q12-q13.1 in human and on 19B in mice. Clues about the role of MTA2 in gene expression came from the association of MTA2 polypeptides in the NuRD complex in a proteomic study This was followed by targeted cloning of murine Mta2 in 2001. MTA2 was initially recognized as an MTA1 like 1 gene, named MTA1-L1, from a large scale sequencing of randomly selected clones from human cDNA libraries in 1999. MTA2 is overexpressed in human cancer and its dysregulated level correlates well with cancer invasiveness and aggressive phenotypes. Similar to the founding family member MTA1, MTA2 functions as a chromatin remodeling factor and regulates gene expression. MTA2 protein localizes in the nucleus and is a component of the nucleosome remodeling and the deacetylation complex ( NuRD). MTA2 is the second member of the MTA family of genes. Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene. regulation of signal transduction by p53 class mediator.positive regulation of transcription by RNA polymerase II.negative regulation of transcription, DNA-templated.negative regulation of transcription by RNA polymerase II.regulation of transcription, DNA-templated.
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